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Structure Investigation of Poly(vinyl alcohol)-Collagen Composite

Qiqing ZHANG , Lei REN and Lingrong LIU(Institute of Biomedical Engineering , Chinese Academy of Medical Sciences , Tianjin 300192 , China)Chun WANG(CCCD , University of Utah , Salt Lake City , UT84112 , USA)

材料科学技术(英)

Naturally derived collagen protein was mixed thoroughly with medical grade poly (vinyl alcohol)(PVA) at the ratio of 90:10 (w/w) and was crosslinked by formaldehyde to form a homogeneous composite membrane. The buIk structure of the membrane was characterized ly means of Xray diffraction (XRD) and transmission electron microscoor (TEM). The membrane surface Structure was investigated using Fourier transform-infrared spectroscopy (attenuated totalrefraction) (FTIR-ATR), electron spectroscopy for chemical analysis (ESCA) and contact angle measurement. lt was found that collagen and PVA can remain Stable. This was supported by the fact that no sign of phase separation had been observed. The use of crosslinking agent can Substantially influence the Structure of the composite. It is suggested that this new compositedeserves further investigation and is potentially usable as a biomedical material.

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